Maculopathy Associated with Tacrolimus (FK 506)

Maculopathy Associated with Tacrolimus (FK 506)

A 63-year-old man with a history of liver transplantation presented to our clinic complaining of visual disturbance. He had been receiving tacrolimus (FK 506) for 30 months (6 mg/day for 2 years and 3 mg/day for 6 months); he reported that the visual disturbance began while taking tacrolimus. A full ophthalmologic examination and electrophysiologic and imaging studies were performed. The best c...

Tacrolimus ( FK 506 ) and the Pharmaceuticall Academid Regulatory Gauntlet

• The pivotal Issue of transplant rejection diagnosis and management Is design, conduct, and analysis of clinical trials. The historical experience with clinical trials of major immunosuppressive drugs (cyclosporine and especially tacrollmus) Is examined in this article. Cyclosporlne was a turning point In transplantation, providing an extraordinary Improvement over previous therapies. Addition...

Adverse effects associated with the use of FK 506.

~, .:1 C (CyA)-based immunosuppression slgmficantly enhanced both patient and graft survival in all solid organ transplants. when compared to the era of azathioprine and steroids. The widespread use ofCyA has spawned a growing body of experience delineating the side effects of Cy A use. which was apparent in the first reports on human patients.' Prior to the utilization of monitoring techniques...

Notes on FK 506.

FK 506 versus cyclosporine.